In this multicenter study, we examine high- and low-frequency mood changes with ambulatory assessment (AA) in young patients suffering from bipolar disorder, borderline personality disorder, and ADHD at five different study sites. Over one year, next to e-diaries, we use digital phenotyping to gain better insight into people's behavior, such as activity or communication behavior. To analyze patterns of affective dynamics, we extend the DynAffect model, which proposes a person-specific affective homebase reflecting an organism’s main affective state, by proposing a second (or third, respectively) affective homebase during depressive (or manic) episodes. Moreover, we will examine the impact of stress, sleep, and polygenic risk scores on the parameters of the Modified DynAffect model.

Term

• 36 months

Participating institutions

• Prof. Dr. Andreas Reif, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University Frankfurt
• Prof. Dr. J. Antoni Ramos-Quiroga, Vall d’Hebron Research Institute, Barcelona
• Prof. Dr. Giovanni de Girolamo, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia
• Prof. Dr. Jan Haavik, University of Bergen; Prof. Dr. Nader Perroud, University Hospitals of Geneva